Dr. David Konrad - Faculty for Chemistry and Pharmacy

Publications

The full list of publications can also be found on PubMed and ORCID.

# equally contributing co-first authors; * co-corresponding authors.

  1. "Optical Control of TRPM8 Channels with Photoswitchable Menthol”
    J. Becker#, C. S. Ellerkmann#, H. Schmelzer#, C. Hermann, K. Lützel, T. Gudermann, D. B. Konrad*, D. Trauner*, U. Storch*, and M. Mederos y Schnitzler*
    Angew. Chem. Int. Ed. 2024, doi: 10.1002/anie.202416549.

  1. "A platform for the development of highly red-shifted azobenzenes”
    K. Lützel#, H. Laqua#, J. K, Szántó, G. Savasci, L, Allmendinger, B. Kicin, V. Ruf, K, Karaghiosoff, A. M. Ali, C. Ochsenfeld* and D. B. Konrad*
    ChemRxiv 2024, doi: 10.26434/chemrxiv-2024-9wbz4.

  1. "Chemical tools to expand the ligandable proteome: diversity-oriented synthesis-based photoreactive stereoprobes”
    D. Ogasawara*, D. B. Konrad, Z. Y. Tan, K. L. Carey, J. Luo, S. J. Won, H. Li, T. Carter, K. E. DeMeester, E. Njomen, S. L. Schreiber, R. J. Xavier, B. Melillo*, B. F. Cravatt*
    Cell Chem. Biol. 2024, doi: 10.1016/j.chembiol.2024.10.005.

  1. "Photoswitchable TRPC6 channel activators evoke distinct channel kinetics reflecting different gating behaviors”
    M. Keck, C. Hermann, K. Lützel, T. Gudermann, D. B. Konrad, M. Mederos y Schnitzler*, Ursula Storch*
    iScience 2024, 27, 111008.

  1. "Ferroptosis in Health and Disease”
    C. Berndt, H. Alborzini, V. Skafar Amend, S. Ayton, U. Barayeu, A. Bartelt, H. Bayir, C. M. Bebber, K. Birsoy, J. P. Böttcher, S. Brabletz, T. Brabletz, A. R. Brown, B. Brüneg, G. Bulli, A. Bruneau, Q. Chen, G. M. DeNicola, T. P. Dick, A. Distéfano, S. Dixon, J. B. Engler, J. Esser-von Bieren, M. Fedorova, J. P. Friedmann Angeli, M. A. Friese, D. C. Fuhrmann, A. J. García-Sáez, K. Garbowicz, M. Götz, W. Gu, L. Hammerich, B. Hassannia, X. Jiang, A. Jeridi, J. P. Kang, V. E. Kagan, D. B. Konrad, S. Kotschi, P. Lei, M. le-Tertre, S. Lev, D. Liang, A. Linkermann, C. Lohr, S. Lorenz, T. Lüdde, A. Methner, B. Michalke, A. V. Milton, J. Min, E. Mishima, S. Müller, H. Motohashi, M. Muckenthaler, S. Murakami, J. A. Olzmann, G. Pagnussat, Z. Pan, T. Papagiannakopoulos, L. Pedrera Puentes, D. A. Pratt, B. Proneth, L. Ramsauer, R. Rodriguez, Y. Saito, F. Schmidt, C. Schmitt, A. Schulze, A. Schwab, A. Schwantes, M. Soula, B. Spitzlberger, B. R. Stockwell, L. Thewes, O. Thorn-Seshold, S. Toyokuni, W. Tonnus, A. Trumpp, P. Vandenabeele, T. Vanden Berghe, V. Vikantaraman, F. C. E. Vogel, S. von Karstedt, F. Wang, F. Westermann, M. Wölk, K. Wu, X. Yang, F. Yu, Y. Zou, and M. Conrad*
    Redox Biology 2024, 75, 103211.

  1. "Assessing the activity of benzodioxol, phenol and aniline derivatives as radical trapping antioxidants that inhibit ferroptosis”
    H. B. E. Schricker#, M. M. Mouzayek#, J. Wanninger, H. Zahran, K. Lützel, A. V. Milton, E. Mishima, T. Nakamura, B. Proneth, M. Conrad, D. B. Konrad*
    ChemRxiv 2024, doi: https://doi.org/10.26434/chemrxiv-2024-v2kgp.

  1. "7-Dehydrocholesterol is an endogenous suppressor of ferroptosis”
    F. P. Freitas#, H. Alborzinia#, A. Ferreira dos Santo#, P. Nepachalovich, L. P. Puentes, O. Zilka; A. Inague, C. Klein, N. Aroua, K. Kausha, B. Kast, S. M. Lorenz, V. Kunz, H. Nehring, T. Nishida Xavier da Silva, Z. Chen, S. G. Doll, E. L. Schaefer, I. Ekpo, W. Schmitz, A. Horling, P. Imming, S. Miyamoto, A. Wehmann, T. C. Genaro-Mattos, K. Mirnics, L. Kumar, J. Klein-Seetharaman, S. Meierjohann, I. Weigand, M. Kroiss, G. W. Bornkamm, F. Gomes, L. E. Soares Netto, M. B. Sathian, D. B. Konrad, D. Covey, B. Michalke , K. Bommert, R. C. Bargou, A. Garcia-Saez, D. A. Pratt, M. Fedorova, A. Trumpp, M. Conrad, J. P. Friedmann Angeli*
    Nature 2024, 626, 401–410.

  1. "Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning”
    D. F. Nippa#, K. Atz#, R. Hohler, A. T. Müller, A. Marx, C. Bartelmus, G. Wuitschik, I. Marzuoli, V. Jost, J. Wolfard, M. Binder, A. F. Stepan, D. B. Konrad*, U. Grether*, R. E. Martin*, G. Schneider*
    Nat. Chem. 2024, 16, 239–248

  1. "Identifying opportunities for late-stage C-H alkylation with high-throughput experimentation and in silico reaction screening”
    D. F. Nippa#, K. Atz#, A. T. Müller, J. Wolfard, M. Binder, C. Isert, M. Binder, O. Scheidegger, D. B. Konrad*, U. Grether*, R. E. Martin*, G. Schneider*
    Commun. Chem. 2023, 6, 256.

  1. "Simple User-Friendly Reaction Format”
    D. F. Nippa#, A. T. Müller#, K. Atz#, D. B. Konrad*, U. Grether*, R. E. Martin*, G. Schneider*
    ChemRxiv 2023, doi:10.26434/chemrxiv-2023-nfq7h-v2.

  1. "Photoswitchable Inhibitors of the Sarco(endo)plasmic Calcium Pump”
    S. J. Hjorth-Jensen#, D. B. Konrad#, E. M. H. Quistgaard, L. C. Hansen, A. Novak, H. Chu, M. Jurášek, T. Zimmermann, J. L. Andersen, P. S. Baran, P. Nissen*, D. Trauner*
    ChemRxiv 2023, doi:10.26434/chemrxiv-2023-bl1xc.

  1. "DNA mimic foldamers affect chromatin composition and disturb cell cycle progression”
    V. Kleene, V. Corvaglia, E. Chacin, I. Forne, D. B. Konrad, P. Khosravani, C. Douat, C. F. Kurat, I. Huc, A. Imhof*
    Nucleic Acids Res. 2023, gkad681, doi:10.1093/nar/gkad681.

  1. “Postsynthetic Photocontrol of Giant Liposomes via Fusion-Based Photolipid Doping”
    S. D. Pritzl*, J. Morstein, S. Kahler, D. B. Konrad, D. Trauner, T. Lohmüller*
    Langmuir 2022, 38, 11941–11949.

  1. “A concise synthesis of tetrodotoxin”
    D. B. Konrad#, K.-P. Ruehmann#, H. Ando, B. Hetzler, N. Strassner, K. N. Houk, B. Matsuura#*, D. Trauner*
    Science 2022, 377, 411–415.

  1. “Late-stage Functionalization and its Impact on Modern Drug Discovery”
    D. F. Nippa, R. Hohler, A. F. Stepan, U. Grether, D. B. Konrad*, R. E. Martin*
    Chimia 2022, 76, 258–260.

  1. “Epithelial-mesenchymal transition and H2O2 signaling – a driver of disease progression and a vulnerability in cancers”
    Anna V. Milton, D. B. Konrad*
    Biol. Chem. 2022, 403, 377-390.

  1. “Optical Membrane Control with Red Light Enabled by Red-Shifted Photolipids”
    S. D. Pritzl#, D. B. Konrad#, M. F. Ober, A. F. Richter, J. A. Frank, B. Nickel, D. Trauner*, T. Lohmüller*
    Langmuir 2022, 38, 385–393.

  1. “A selective photoswitchable allosteric agonist of a G protein-coupled receptor”
    P. Donthamsetti#, D. B. Konrad#, B. Hetzler, Z. Fu, D. Trauner*, E. Y. Isacoff*
    J. Am. Chem. Soc. 2021, 143, 8951–8956.

  1. “Photolipid Bilayer Permeability is Controlled by Transient Pore Formation”
    S. D. Pritzl, P. Urban, A. Prasselsperger, D. B. Konrad, J. A. Frank, D. Trauner*, T. Lohmüller*,
    Langmuir 2020, 36, 13509–13515.

  1. “In vivo photopharmacology enabled by multifunctional fibers”
    J. A. Frank*, M.-J. Antonini, P.-H. Chiang, A. Canales, D. B. Konrad, I. Garwood, G. Rajic, F. Koehler, Y. Fink, P. Anikeeva*,
    ACS Chem. Neurosci. 2020, 11, 3802–3813.

  1. “Light-induced lipid mixing implies a causal role of lipid splay in membrane fusion”
    H. A. Scheidt#, K. Kolocaj#, D. B. Konrad, J. A. Frank, D. Trauner, D. Langosch*, D. Huster*,
    BBA - Biomembranes 2020, 1862, 183438.

  1. “An activity-guided map of electrophile-cysteine interactions in primary human immune cells”
    E. V. Vinogradova,* X. Zhang, D. Remillard, D. C. Lazar, R. M. Suciu, Y. Wang, G. Bianco, Y. Yamashita, V. M. Crowley, M. A. Schafroth, M. Yokoyama, D. B. Konrad, K. M. Lum, G. M. Simon, E. K. Kemper, M. R. Lazear, S. Yin, M. M. Blewett, M. M.Dix, N. Nguyen, M. N. Shokhirev, E. Chin, L. Lairson, B. Melillo, S. L. Schreiber, S. Forli, J. R. Teijaro,* B. F. Cravatt*,
    Cell 2020, 182, 1009–1026.

  1. “Computational Design and Synthesis of a Deeply Red-Shifted and Bistable Azobenzene”
    D. B. Konrad#*, G. Savasci#, L. Allmendinger, D. Trauner, C. Ochsenfeld*, A. M. Ali*,
    J. Am. Chem. Soc. 2020, 142, 6538–6547.

  1. “A Lipid Photoswitch Controls Membrane Fluidity in Supported Bilayer Membranes”
    P. Urban#, S. D. Pritzl#, M. F. Ober#, C. F. Dirscherl, C. Pernpeintner, D. B. Konrad, J. A. Frank, D. Trauner*, B. Nickel*, T. Lohmüller*,
    Langmuir 2020, 36, 2629–2634.

  1. “Concise Asymmetric Synthesis of Kweichowenol A”
    D. B. Konrad, B. Kicin, D. Trauner*,
    Synlett 2019, 30, 383–386.

  1. “Light-Controlled Lipid Interaction and Membrane Organization in Photolipid Bilayer Membranes”
    P. Urban, S. D. Pritzl, D. B. Konrad, J. A. Frank, C. Pernpeintner, C. R. Roeske, D. Trauner*, T. Lohmüller*,
    Langmuir 2018, 34, 13368–13374.

  1. “PhoDAGs Enable Optical Control of Diacylglycerol-Sensitive Transient Receptor Potential Channels.”
    T. Leinders-Zufall, U. Storch, K. Bleymehl, M. Mederos y Schnitzler, J. A. Frank, D. B. Konrad, D. Trauner, T. Gudermann, F. Zufall*,
    Cell Chem. Biol. 2017, 25, 215–223.

  1. “Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors.”
    J. Levitz, J. Broichhagen, P. Leippe, D. Konrad, D. Trauner*, E. Y. Isacoff*,
    Proc. Natl. Acad. Sci. 2017, 114, 3546–3554.

  1. “Selective Lithiation, Magnesiation and Zincation of Unsymmetrical Azobenzenes Using Continuous Flow.”
    M. Ketels, D. B. Konrad, K. Karaghiosoff, D. Trauner, P. Knochel*,
    Org. Lett. 2017, 19, 1666–1669.

  1. “Optical Control of GIRK Channels Using Visible Light.“
    J. B. Trads, J. Burgstaller, L. Laprell, D. B. Konrad, L. de la Rosa de la Osa, C. D. Weaver, H. Baier, D. Trauner*, D. M. Barber*,
    Org. Biomol. Chem. 2017, 15, 76–81.

  1. “Synthesis of Redshifted Azobenzene Photoswitches via Late-Stage Functionalization.“
    D. B. Konrad, J. A. Frank, D. Trauner*,
    Chem. Eur. J. 2016, 22, 4364–4368.

  1. “Orthogonal Optical Control of a G Protein-Coupled Receptor with a SNAP-Tethered Photochromic Ligand.“
    J. Broichhagen, A. Damijonaitis, J. Levitz, K. R. Sokol, P. Leippe, D. Konrad, E. Y. Isacoff*, D. Trauner*,
    ACS Cent. Sci. 2015, 1, 383–393.